Actor portrayal

Hand with a small amount of ZORYVE topical foam
Hand with a small amount of ZORYVE topical foam

Clearance Rates

Dramatic 77% IGA Success at Week 82*

SIMPLIFY SEBORRHEIC DERMATITIS CONTROL

IGA SUCCESS AT WEEK 8

IGA OF CLEAR AT WEEK 8

RESULTS AS EARLY AS WEEK 21,2

IGA Success: Clear/Almost Clear + ≥2-grade improvement

†P<0.0001.0ZORYVE (n=458)WEEK 2WEEK 4WEEK 8Vehicle (n=225) (HYDROARQ TECHNOLOGY™)10050PERCENTAGE OF PATIENTS68%†41%†77%†22%42%53%
0ZORYVE (n=458)Vehicle (n=225) (HYDROARQ TECHNOLOGY™)WEEK 2WEEK 4WEEK 8†P<0.0001.PERCENTAGE OF PATIENTS1008060402068%†41%†77%†22%42%53%

51% WERE COMPLETELY CLEAR
(IGA=0) AT WEEK 8 IN STRATUM1

IGA = Investigator Global Assessment.

‡P=0.0001.§P<0.0001.0ZORYVE (n=304)WEEK 2WEEK 4WEEK 8Vehicle (n=153) (HYDROARQ TECHNOLOGY™)10050PERCENTAGE OF PATIENTS36%§6%16%‡51%§15%28%
‡P=0.0001.§P<0.0001.0ZORYVE (n=304)Vehicle (n=153) (HYDROARQ TECHNOLOGY™)WEEK 2WEEK 4WEEK 8PERCENTAGE OF PATIENTS1008060402036%§16%‡51%§6%15%28%

*Trial 203 and STRATUM studies evaluated ZORYVE (n=458) vs vehicle (n=225) once daily for 8 weeks in patients with seborrheic dermatitis. The primary endpoint was IGA Success at Week 8, defined as a score of Clear (0) or Almost Clear (1) and a ≥2-grade improvement from baseline. Secondary endpoints in STRATUM (ZORYVE (n=304); vehicle (n=153)) included IGA of Clear (0) at Week 8 and WI-NRS Success, defined as a ≥4-point improvement for patients with a baseline score of ≥4. WI-NRS scale: 0 (no itch) to 10 (worst imaginable itch).

IN STRATUM
51% WERE COMPLETELY CLEAR (IGA=0) AT WEEK 8 vs 28% ON VEHICLE3

SIGNIFICANT ITCH RELIEF AT WEEK 8 AND AS EARLY AS WEEK 2 IN STRATUM1,3

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