Hand holding ZORYVE steroid-free cream

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Hand holding ZORYVE steroid-free cream

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 Clearance Rates

RAPID, RELIABLE RESULTS ANYWHERE FOR PLAQUE PSORIASIS

 

POWERFUL SKIN CLEARANCE AT WEEK 8

See the results at Week 8

Primary
Endpoint

IGA Success*

Key Secondary
Endpoint

I-IGA Success

5x more patients achieved IGA Success at Week 8 vs vehicle

(% of patients achieving IGA Success)1,2

20%40%5%7%ZORYVE(n=576)Vehicle(n=305)WEEK 2WEEK 4WEEK 6WEEK 82%4%29%P<0.001 vs vehicle, nominal.5%
P<0.001 vs vehicle, nominal.ZORYVE(n=576)Vehicle(n=305)5%20%29%2%4%5%7%40%WEEK 2WEEK 4WEEK 6WEEK 8

Data are pooled analyses of the DERMIS-1 and DERMIS-2 studies.

 

IGA Success rates at Week 8 were consistent regardless of baseline BSA involvement

(mild, moderate, severe)7

70% of patients achieved I-IGA Success at Week 8

(% of patients achieving I-IGA Success)1,2

§P<0.05 vs vehicle, nominal. ||P<0.01 vs vehicle, nominal.WEEK 2WEEK 4WEEK 6WEEK 8ZORYVE(n=116)Vehicle(n=63)35%§47%§70%||10%23%57%||18%16%
ZORYVE(n=116)Vehicle(n=63)47%§57%||10%23%18%16%70%||WEEK 2WEEK 4WEEK 6WEEK 8§P<0.05 vs vehicle, nominal.||P<0.01 vs vehicle, nominal.35%||§

Data are pooled analyses of the DERMIS-1 and DERMIS-2 studies.

3 out of 4 patients achieved Clear or Almost Clear
skin in intertriginous areas with ZORYVE (75%, n=116)
vs vehicle (23%, n=63)7

 
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Nearly all patients had IMPROVED CLINICAL SIGNS with ZORYVE8

9 out of 10 (95%) had any PASI improvement at Week 8 vs 71% with vehicle

40% achieved PASI-75 at Week 8 vs 7% with vehicle

12% achieved PASI-100 (complete response) at Week 8 vs 1% with vehicle

*IGA Success = Achievement of Clear (0)/Almost Clear (1) and a ≥2-grade improvement from baseline.

I-IGA Success = Achievement of Clear (0)/Almost Clear (1) and a ≥2-grade improvement from baseline.

Pooled PASI response rates (N=881). Analysis provides a summary of PASI improvement for every patient in DERMIS-1 and DERMIS-2. PASI response rates are defined as percentage of patients with improved PASI scores from baseline to Week 8. PASI scores evaluate the following plaque psoriasis symptoms: erythema, skin thickness (induration), and desquamation (scaling).

BSA = Body Surface Area.

PASI = Psoriasis Area and Severity Index.

PASI-75 = 75% reduction in PASI score from baseline.

PASI-100 = 100% reduction in PASI score from baseline.